This is a breed in need of early socialization and reasonably firm handling. The Argentinian Mastiff is protective and territorial, a good choice for a property watchdog and personal guardian, but while this is undoubtedly a tough working breed, it is quite sensitive and gentle, at times even described by some owners as a "needy" dog. Exceptionally devoted to its master, the Dogo Argentino is affectionate towards children, making it an excellent household pet. There are still some health issues, like skin problems due to the extreme lack of pigmentation encountered in certain lines, as well as a high rate of inherited deafness and kidney diseases, but these traits are on their way of being eliminated through careful breeding. The ears are usually cropped, although unaltered dogs can be seen too.

The coat is short, flat and smooth. The colour is always solid white, but very small dark markings on the head are acceptable. Average height is around 26 inches.